Edible vaccines? The future of immunization
Keywords:
Vaccine, Plants, ImmunityAbstract
Can you imagine getting vaccinated just by eating a salad? Edible vaccines will soon become a reality, with potatoes, tomatoes, or lettuce producing viral proteins, the very ones your immune system needs to recognize to protect you. By consuming these vegetables, you could activate your defenses without the need for needles. This revolutionary technology would not only simplify vaccination but also eliminate the need for refrigeration, which is crucial for reaching remote areas. Although there are still challenges to overcome, each advance brings us closer to a future where disease prevention could be as simple as eating.
References
Hager, K. J., Pérez Marc, G., Gobeil, P., Diaz, R. S., Heizer, G., Llapur, C., Makarkov, A. I., Vasconcellos, E., Pillet, S., Riera, F., Saxena, P., Geller Wolff, P., Bhutada, K., Wallace, G., Aazami, H., Jones, C. E., Polack, F. P., Ferrara, L., Atkins, J., … Ward, B. J. (2022). Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. New England Journal of Medicine, 386(22), 2084–2096. https://doi.org/10.1056/NEJMoa2201300
Arakawa, T., Chong, D. K. X., & Langridge, W. H. R. (1998). Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nature Biotechnology, 16(3), 292–297. https://doi.org/10.1038/nbt0398-292
Pniewski, T., Kapusta, J., Bociąg, P., Wojciechowicz, J., Kostrzak, A., Gdula, M., Fedorowicz-Strońska, O., Wójcik, P., Otta, H., Samardakiewicz, S., Wolko, B., & Płucienniczak, A. (2011). Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation. Journal of Applied Genetics, 52(2), 125–136. https://doi.org/10.1007/s13353-010-0001-5
Yusibov, V. (2002). Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine. Vaccine, 20(25–26), 3155–3164. https://doi.org/10.1016/S0264-410X(02)00260-8
Dus Santos, M. J., Carrillo, C., Ardila, F., Ríos, R. D., Franzone, P., Piccone, M. E., Wigdorovitz, A., & Borca, M. V. (2005). Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen. Vaccine, 23(15), 1838–1843. https://doi.org/10.1016/j.vaccine.2004.11.014

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