From caterpillars to vaccines: how vaccines are produced using insect cells and baculoviruses
Keywords:
Insect cells, baculovirus, vaccines, recombinant proteinAbstract
Can you imagine a small caterpillar helping us produce vaccines? This is now a reality thanks to the insect cell-baculovirus system, which can produce proteins used in current vaccines. In products such as the recombinant influenza vaccine Flublok®, this system avoids the use of embryonated eggs and enables antigen production through recombinant biotechnology. Insect cell-based technologies have also been used in approved vaccines against influenza, HPV, and COVID-19, and they are being explored to produce other proteins of biomedical interest.
References
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