Molecular switches: Orchestrating gene expression through promoters
Potential use in therapeutic gene treatments
Keywords:
Gene therapy, specific promoters, targeted treatmentsAbstract
Gene expression, essential for cellular function and protein production, is regulated by promoters acting as molecular switches, controlling the transcription of DNA to messenger RNA through transcription factors and RNA polymerase II. These promoters, with specific regulatory elements, ensure precise transcription and are key in gene therapy strategies, allowing for the targeting of therapeutic genes to specific cells or tissues, thus avoiding effects on healthy cells. Tissue-specific and tumor-specific promoters allow establishing strategies for treating genetic diseases and cancer, respectively, through selective activation in target cells, optimizing the safety and efficacy of the treatment.
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