Peroxiredoxins: antioxidant enzymes and their importance in the cardiovascular model
Keywords:
Oxidative stress, peroxiredoxins, redox signalling.Abstract
Peroxiredoxins (Prxs) are key antioxidant enzymes that regulate oxidative stress in the cell, a downregulation is implicated in cardiovascular, degenerative diseases and cancer. Their action mechanism is based in the reduction of peroxides by a conserved redox mechanism and are grouped into three subfamilies according to their cysteine residues: Typical 2-Cys, Atypical 2-Cys and 1-Cys. In addition to their function as peroxidases, Prxs modulate redox signalling and programmed cell death. This article reviews the Prdxs classification, mechanisms and research relevance, with an emphasis on the cardiovascular system.
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