Iron and anemia: How the body regulates an essential trace element

Authors

  • Jacqueline Rodríguez-Ramos Instituto Tecnológico y de Estudios Superiores de Monterrey (ITESM), Eugenio Garza Sada 2501, 64700, Monterrey, Nuevo León, México.
  • Eristeo García-Márquez Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), Unidad Noreste, Parque PIIT, Vía de La Innovación 404, 66628, Apodaca, Nuevo León, México.

Keywords:

Iron-deficiency anaemia, iron bioavailability, supplementation and fortification

Abstract

Iron plays a critical role in oxygen transport and numerous metabolic processes essential for human health. Iron deficiency is the leading cause of iron-deficiency anemia, one of the most prevalent nutritional disorders worldwide and a major public health concern, particularly among children, women of reproductive age, and older adults. Although effective strategies are available for its prevention and treatment, natural alternatives have received comparatively less scientific attention. This review examines iron metabolism, absorption, and regulation, as well as conventional and natural strategies for the prevention and treatment of iron-deficiency anemia.

References

Cotoraci, C., Ciceu, A., Sasu, A., & Hermenean, A. (2021). Natural antioxidants in anemia treatment. International Journal of Molecular Sciences, 22(4), Article 1883. https://doi.org/10.3390/ijms22041883

González-Meza, G. M., Elizondo-Luevano, J. H., Peña-Borrayo, A., Martínez-Ávila, G. C. G., Garzoli, S., Kačániová, M., García-Márquez, E., & Castillo-Hernández, S. L. (2026). Common beans (Phaseolus vulgaris L.) as a sustainable nutritional strategy to mitigate iron deficiency anemia. Chemistry & Biodiversity, 23(6), e03651. https://doi.org/10.1002/cbdv.202503651

Obeagu, E. I. (2026). Hemoglobin and human longevity: Integrating oxygen transport, redox biology, and aging pathways—A narrative review. Annals of Medicine & Surgery, 88, 580–586. https://doi.org/10.1097/MS9.0000000000004508

Wacka, E., Nicikowski, J., Jarmuzek, P., & Zembron-Lacny, A. (2024). Anemia and its connections to inflammation in older adults: A review. Journal of Clinical Medicine, 13, Article 2049. https://doi.org/10.3390/jcm13072049

Zhong, M., Wang, Y., Min, J., & Wang, F. (2025). Iron metabolism and ferroptosis in human health and disease. BMC Biology, 23. https://doi.org/10.1186/s12915-025-02378-6

Horváth, A., Tamási, K., Pap, R., Jánosa, G., & Pandur, E. (2026). Iron, the essential micronutrient: A comprehensive review of regulatory pathways of iron metabolism. Nutrients, 18, Article 109. https://doi.org/10.3390/nu18010109

Liberal, Â., Pinela, J., Vívar-Quintana, A. M., Ferreira, I. C. F. R., & Barros, L. (2020). Fighting iron-deficiency anemia: Innovations in food fortificants and biofortification strategies. Foods, 9(12), Article 1871. https://doi.org/10.3390/foods9121871

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Published

2026-07-24

How to Cite

Rodríguez-Ramos, J., & García-Márquez, E. (2026). Iron and anemia: How the body regulates an essential trace element. Revista De divulgación científica IBIO, 9(1), 365. Retrieved from http://revistaibio.com/ojs33/index.php/main/article/view/365

Issue

Vol. 9 No. 1 (2027)

Section

Hot Science

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