Biochemistry through time and space: A perspective from mathematical modeling

Authors

  • Bruno Alberto Ortiz Garcia División de Ingeniería Química y Bioquímica, TecNM: Tecnológico de Estudios Superiores de Ecatepec, C.P. 55210, Ecatepec de Morelos, Estado de México, México.
  • María Isabel Neria-González División de Ingeniería Química y Bioquímica, TecNM: Tecnológico de Estudios Superiores de Ecatepec, C.P. 55210, Ecatepec de Morelos, Estado de México, México.
  • Ricardo Aguilar-López Departamento de Biotecnología y Bioingeniería, CINVESTAV-IPN, C.P. 07360, San Pedro Zacatenco, CDMX, México.

Keywords:

Systems biology, Bioinformatics, Biological systems

Abstract

Life, understood as a complex system, has been studied through mathematical modeling for over a century. This approach has been fundamental since its earliest simplified versions, and its scope has expanded thanks to advanced computing and sophisticated algorithms. Despite these advances, challenges remain in experimental validation and in the interpretation of large volumes of data. In this context, computer simulations, supported by tools from bioinformatics and systems biology, allow for more accurate data interpretation, enhancing our understanding and predictive capacity of living organisms.

References

Feig, M., & Sugita, Y. (2019). Whole-Cell Models and Simulations in Molecular Detail. Annual Review Of Cell And Developmental Biology, 35(1), 191-211. https://doi.org/10.1146/annurev-cellbio-100617-062542

Smith, R. W., & Fleck, C. (2017). Derivation and use of mathematical models in systems biology. In Pollen Tip Growth: From Biophysical Aspects to Systems Biology (pp. 339-367). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-56645-0_13

Lucido, A., Basallo, O., Marin-Sanguino, A., Eleiwa, A., Martinez, E. S., Vilaprinyo, E., Sorribas, A., & Alves, R. (2025). Multiscale Mathematical Modeling in Systems Biology: A Framework to Boost Plant Synthetic Biology. Plants, 14(3), 470. https://doi.org/10.3390/plants14030470

Saltelli, A., & Di Fiore, M. (Eds.). (2023). The politics of modelling: Numbers between science and policy. Oxford University Press. https://doi.org/10.1093/oso/9780198872412.001.0001

Zupanic, A., Bernstein, H. C., & Heiland, I. (2020). Systems biology: current status and challenges. Cellular And Molecular Life Sciences, 77(3), 379-380. https://doi.org/10.1007/s00018-019-03410-z

Aguilar López, R. (2024). Fermentation Processes. Modeling, Optimization and Control. MDPI. https://www.mdpi.com/books/reprint/10183-fermentation-processes-modeling-optimization-and-control

Published

2026-01-08

How to Cite

Ortiz Garcia, B. A., Neria-González, M. I., & Aguilar-López, R. (2026). Biochemistry through time and space: A perspective from mathematical modeling. Revista De divulgación científica IBIO, 8(1), 252. Retrieved from http://revistaibio.com/ojs33/index.php/main/article/view/252