Exploring open data in biomedicine: A practical introduction to using GEO and GEO2R
Keywords:
GEO, accessible bioinformatics, open biomedical dataAbstract
The NCBI Gene Expression Omnibus (GEO) is a public repository containing thousands of gene expression studies and other molecular profiles. Reusing these open data makes it possible to generate hypotheses, validate findings, and perform exploratory in silico analyses without laboratory costs. In this article, we explain in simple language what GEO is, what information it contains, and how to use accessible tools such as GEO2R to perform basic reproducible analyses, even in institutions with limited resources. We also present an illustrative example of the workflow and potential results, without establishing definitive biological or clinical conclusions.
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